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反应结晶是指气体与液体或液体与液体之间进行化学反应产生难溶或不溶固相物质的过程。反应结晶法可以使一些易生成沉淀的物质与其它化合物分离，从而达到纯化的目的。
反应结晶过程有高选择性的特点，常用于产品的分离提纯。
Reaction crystallization refers to the chemical reaction between a gas and a liquid or liquid or liquid to produce insoluble or insoluble solid matter. Reactive crystallization can make some easily precipitated substances separate from other compounds, so as to achieve the purpose of purification. The reaction crystallization process is characterized by high selectivity and is often used in the separation and purification of products.
反应结晶的几个影响因素：饱和度，温度，混合均匀度，搅拌强度，物质纯度。
普通结晶罐自动化程度低，两相或多相物料混合，为了达到好的混合效果，搅拌强烈，容易产生大量细晶，当细晶小于1μm 时，细晶会有团聚现象，即范得华力会起作用。因此产品粒度分布过宽，粘度变大，洗涤量增加，离心后晶间包裹的残液量相对增大，导致产品纯度低，另外操作靠经验和简单的指标控制，不同班次工人操作有差异。靠车间管理难解决问题，导致产品批间差异大，粒度分布不均匀，产品质量不稳定；从综合成本考虑，间歇操作繁琐，动力消耗高，不适合批量产品的生产。
Several factors affecting reactive crystallization: degree of saturation, temperature, mixing uniformity, agitation strength, and material purity. The ordinary crystallization tank is low in automation, and when the two phase or multiphase materials are mixed, In order to achieve good mixing effect, the stirring process can be strong and easily producing a lot of fine grains. When the fine grain is less than 1 m, the fine grain will reunion, the Van der Waals force will come into effect. Therefore, when the product size distribution is too wide, the viscosity becomes larger, the washing capacity increases, and the residual liquid content between the crystals increases relatively after centrifugation, the low purity of the product will be caused. In addition, the operation is controlled by experience and simple indicators, and there are differences in the operation of workers in different shifts. The difficulty to solve problems by workshop management results in large differences among the products, uneven distribution of grain size, and unstable quality of products. Considering the comprehensive cost, the intermittent operation is tedious, the power consumption is high, and it is not suitable for the production of mass products.
反应结晶设备解决了上述问题，产品质量达到了国外科学标准。反应结晶过程是一个复杂的传热、传质过程。在不同的物理、化学环境中，结晶过程的控制步骤可能改变，反映不同的行为。特别是药物结晶产品，对产品晶型有严格要求，对产品的粒度分布的也有要求，它直接影响着药物的品质。
The reaction crystallization equipment can completely solve the above problems, and the product quality has reached the foreign advanced standards. The reaction crystallization is a complex process of heat and mass transfer. In different physical and chemical environments, the control steps of the crystallization process may change and reflect different behaviors. Especially for the pharmaceutical crystallization products. They have strict requirements on the crystal type, and also on the particle size distribution of the products, which directly affects the quality of drugs.
ND反应结晶器：设备内部温度，溶液pH值、容易控制。反应结晶器结构简单、能耗低，而且结晶粒度分布均匀，可按要求生产纯度较高的大晶，晶粒均匀易于过滤，对产品的质量是一个大的提高。
ND Crystallizer: easy to control the internal temperature, pH value of solution; simple structure, low energy consumption, uniform distribution of crystals; can produce high-purity large crystal grains based on indications; easy to filter; a great improvement to product quality.
ND反应结晶器内壁和导流筒部分抛光以减少结壁现象
The inner wall and draft tubes of ND Crystallizers are polished to reduce wall scars.
1、可配晶体消除装置；上部微细晶体进细晶消除器后变为过饱和溶液回结晶器继续结晶。
equipped with crystal elimination device; The upper micro crystal enters the fine crystal eliminator and then becomes supersaturated solution, continues to crystallize.
2、结晶器下部装淘洗腿，有利于比重大的晶体采出。
The lower part of the crystallizer is provided with a panning leg, which is beneficial to the extraction of the larger crystals.
3、如果需要，可以设置晶种加入器，加入晶种进一步改善产品粒度分布。
If necessary, the crystal seed feeder can be added to further improve the particle size distribution
4、结晶器可以调整反应结晶温度，参照好的反应速率来设定。
we can adjust the reaction crystallization temperature according to the optimum reaction rate
5、结晶机工作电压：380V；设备工作时间：24h/d；
Operating voltage: 380V; working time: 24h/d
6、自控部分：根据自控部分的设计要求，系统可实现以下目标：
Automatic control part: according to the design requirements of the automatic control part, the system can achieve the following goals:
（1）各控制器的技术参数，保证工艺上的要求，能够自动监测控制结晶温度等指标，泵采用变频控制，进、出料作业能够自动控制；
The technical parameters of each controller ensure the requirements of the process, and can automatically monitor and control the crystal temperature and other indicators. The pump adopts frequency conversion control, and the feed and discharge operations can be automatically controlled;
（2）现场执行机构有系统信息上传接口，可接入DCS系统。
The field executing organization has the system information uploading interface, and can access the DCS system.
