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苏州艾特森制药设备有限公司
苏州艾特森制药设备有限公司
苏州艾特森制药设备有限公司主营脂质体挤出器,台式脂质体挤出器,微流控,微流控芯片,LNP微流控,mRNA微流控,实验型旋转灭菌柜,SiRNA脂质体,mRNA脂质体,阳离子脂质体,脂质体制备,疫苗脂质体,疫苗脂质体,核酸脂质体,挤出仪,双螺杆热熔挤出机,立式灭菌柜,高压均质机,剪切机,公司位于苏州工业园区,是一家自主研发、专业生产及销售制药装备的科技生产型企业!
TLEx 罐体式脂质体挤出器
TLEx Tank Liposome Extruder
主要应用
◆脂质体 Doxorubicin liposome
◆ 脂质体 Amphotericin B liposome
◆ 脂质体 Paclitaxel liposomes
◆ 脂质体 Oxaliplatin liposomes
◆ 伊立替康脂质体 Irinotecan liposome
◆ SiRNA 脂质体 SiRNA liposome
◆ 白蛋白纳米粒 Albumin paclitaxel nanoparticles
◆ 核酸类脂质体 Nucleic acid liposome
◆ mRNA脂质体 mRNA liposome
挤出原理
Extrusion Principle
挤出原理图
Extrusion schematic diagram
◆样品经过水化形成脂质体后，一般会通过高压均质或者超声的方式对样品进行初步均质处理，处理后样品粒径和分布都会有所提高，但往往还不能达到所需要的理想要求。此时，将均质后样品由下图中进料口进入，通过高压氮气将样品从滤膜中挤出，挤出后的样品粒径和分布都会进一步提高。
After the sample is hydrated to form liposomes, the sample is usually homogenized by high-pressure homogenization or ultrasonic wave. After treatment, the particle size and distribution of the sample will be improved, but it can not meet the desired requirements. At this time, the homogenized sample enters through the feed port in the figure below, and the sample is extruded from the filter membrane by high-pressure nitrogen. The particle size and distribution of the extruded sample will be further improved
支撑板
Support plate
◆支撑板和滤板主要起到支撑滤膜的作用。 由于磷脂有一定的相变温度，所以在挤出之前需要对挤出器夹套通入恒温水进行预热至一定温度（如70℃），且在使用过程中需保持在此温度。通常的脂质体品种挤出之后粒径能达到 100nm以下，PDI 能控制在 0.1 以下。
The supporting plate and filter plate mainly play the role of supporting the filter membrane. Since the phospholipid has a certain phase transition temperature, it is necessary to preheat the extruder jacket with constant temperature water before extrusion to a certain temperature (such as 70 ℃), which should be maintained in the process of use. After extrusion, the particle size of liposomes can reach below 100nm and PDI can be controlled below 0.1.
◆动力源：氮气
Power source: nitrogen
技术特征
Technical features
◆核心部件 The core components
支撑板（SS316L不锈钢）
Support plate (SS316L stainless steel)
滤板（SS316L不锈钢）
Filter plate (SS316L stainless steel)
滤膜:PC材质（聚碳酸酯）
Filter membrane :PC material (polycarbonate)
密封系统：PU材质/聚四氟乙烯
Sealing system: PU material/polytetrafluoroethylene
温控系统：夹套控温
Temperature control system: jacket temperature control
◆技术特点 Technical characteristics
所有部件包括“O"型圈，垫圈均通过FDA 认证
All parts including "O" rings, gaskets are FDA approved
操作便捷，可重复使用
Easy to operate and reusable
严格控制产品粒径，可单次操作或循环操作
Strictly control the particle size of products, single operation or cycle operation
装卸方便，便于清洗和灭菌
Easy loading and unloading, easy cleaning and sterilization
所有数据可直接放大
All data can be directly amplified
预设压力保护阀
Preset pressure protection valve
可用于高浓度样品处理
Can be used for high concentration sample processing
可放在洁净室中使用，符合 GMP 标准
Can be used in a clean room, accord with GMP standards
技术参数
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