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苏州艾特森制药设备有限公司
苏州艾特森制药设备有限公司
苏州艾特森制药设备有限公司主营脂质体挤出器,台式脂质体挤出器,微流控,微流控芯片,LNP微流控,mRNA微流控,实验型旋转灭菌柜,SiRNA脂质体,mRNA脂质体,阳离子脂质体,脂质体制备,疫苗脂质体,疫苗脂质体,核酸脂质体,挤出仪,双螺杆热熔挤出机,立式灭菌柜,高压均质机,剪切机,公司位于苏州工业园区,是一家自主研发、专业生产及销售制药装备的科技生产型企业!
Desktop Liposome Extruder：Extru 25-20
主要应用
The main application
◆脂质体
Liposome doxorubicin
◆两性霉素 B 脂质体
Amphotericin B liposome
◆脂质体
Paclitaxel liposomes
◆脂质体
Oxaliplatin liposomes
◆伊立替康脂质体
Irinotecan liposome
◆SiRNA 脂质体
SiRNA liposome
◆白蛋白纳米粒
Albumin paclitaxel nanoparticles
◆核酸类脂质体
Nucleic acid liposome
◆其他整粒脂质体样品
Other whole li posome samples
挤出原理
Technical features
◆脂质体挤出的原理在于，通过一定的挤出动力源将脂质体样品粒子进行挤压，使其在一定压力条件下通过 PC滤膜， 此压力作为粒子过膜过程中的剪切力可使其达到粒径控制的效果。不论形态、大小和分布都可得到极大改善。
The principle of liposome extrusion is that the particles of liposome sample are extruded by a certain extrusion power source to pass through the PC membrane under a certain pressure. The pressure acts as the shear force in the process of the particles passing through the membrane, which can achieve the effect of particle size control. The shape, size and distribubtion can be greatly improved.
◆支撑板和滤板主要起到支撑滤膜的作用。 由于磷脂有一定的相变温度，所以在挤出之前需要对挤出器夹套通入恒温水进行预热至一定温度（50~60℃），且在使用过程中需保持在此温度。通常的脂质体品种挤出之后粒径能达到 100nm以下，PDI 能控制在 0.1 以下。
The support plate and the filter plate mainly play the role of supporting the filter membrane.Because of phospholipids have certain phase change temperature before extrusion need access to extruder jacket thermostatic water preheated to a certain temperature (50 ~ 60 ℃), and needs to keep the temperature in the process of use.The particle size of the normal liposome can reach below 100nm after extrusion, and the PDI can be controlled below 0.1.
◆动力源：氮气
Power source: nitrogen
技术特征
Technical features
◆核心部件 The core components
支撑板（SS316L不锈钢）
Support plate (SS316L stainless steel)
滤板（SS316L不锈钢）
Filter plate (SS316L stainless steel)
滤膜:PC材质（聚碳酸酯）
Filter membrane :PC material (polycarbonate)
密封系统：PU材质/聚四氟乙烯
Sealing system: PU material/polytetrafluoroethylene
温控系统：夹套控温水
Temperature control system: jacket control warm water
◆技术特点 Technical characteristics
单次样品量少
Low sample consumption
压力高
High extrusion pressure
残留量为"0"
No residue
无需手动操作
No manual operation required
全程可控温
Whole process temperature control
所有部件包括“O"型圈，垫圈均通过FDA 认证
All parts including "O" rings, gaskets are FDA approved
装卸方便，便于清洗和灭菌
Easy loading and unloading, easy cleaning and sterilization
所有数据可直接放大
All data can be directly amplified
可用于高浓度样品处理
Can be used for high concentration sample processing
可放在洁净室中使用，符合 GMP 标准
Can be used in a clean room, in line with GMP standards
型号 MODEL | Extru 25-20 |
压力 [Mpa] The highest pressure[Mpa] | 25 |
最终产品粒径 [nm] Final product size [nm] | 50~1000 |
单批处理量[ml] The Final product size[ml] | 0~20 |
产品浓度[mg/ml] Maximum product concentration[mg/ml] | 200 |
工作温度范围 Operating temperature range | 5~80℃ |
产品材质 Product material | SS316L |
直径[mm] The diameter of | 25 |
动力源类型 | Gas |
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